Selected Publications
For a full listing of publications see Pubmed or Google Scholar.
Italics indicate current/former lab members. * indicates authors contributed equally.
Preprints
Study design and the sampling of deleterious rare variants in biobank-scale datasets.
Steiner MC, Rice DP, Biddanda A, Ianni-Ravn MK, Porras C, & Novembre, J.
[ bioRxiv ]
Distinguishing multiple-merger from Kingman coalescence using two-site frequency spectra.
Rice DP, Novembre J, Desai MM.
[ bioRxiv ]
2023
Use of Race, Ethnicity, and Ancestry as Population Descriptors in Genomics Research.
NASEM Committee
[ National Academies of Science, Engineering, and Medicine Report ]
Mexican Biobank advances population and medical genomics of diverse ancestries.
Sohail M, Palma-Martínez MJ, Chong AY, Quinto-Cortés CD, Barberena-Jonas C, Medina-Muñoz S G, …, Novembre J, Garcia-Garca L & Moreno-Estrada A.
[ Nature, 622(7984), 775-783. ]
Intestinal microbiota of Nearctic‐Neotropical migratory birds vary more over seasons and years than between host species.
Skeen HR, Willard DE, Jones AW, Winger BM, Gyllenhaal EF, Tsuru BR, Hackett SJ, and Novembre J.
[ Molecular Ecology, 32:3290-3307. ]
A rarefaction approach for measuring population differences in rare and common variation.
Cotter DJ, Hofgard EF, Novembre J, Szpiech ZA, & Rosenberg NA.
[ Genetics, 224(2), iyad070. ]
2022
Ancient genomes from the Himalayas illuminate the genetic history of Tibetans and their Tibeto-Burman speaking neighbors.
Liu CC, Witonsky D, Gosling A, Lee JH, Ringbauer H<e/m>, Hagan R, Patel N, Stahl R, Novembre J, Aldenderfer M, Warriner C, Di Rienz A, Jeong C.
[ Nature Communications, 13(1), 1-14. ]
Modeling the spatiotemporal spread of beneficial alleles using ancient genomes.
Muktupavela RA, Petr M, Ségurel L, Korneliussen T, Novembre J, & Racimo F.
[ Elife, 11, e73767. ]
Population genetic models for the spatial spread of adaptive variants- A review in light of SARS-CoV-2 evolution.
Steiner MC, Novembre J.
[ PLoS Genet 18:e1010391 ]
Properties of 2-locus genealogies and linkage disequilibrium in temporally structured samples.
Biddanda A, Steinrücken M, Novembre J.
[ Genetics 221(1):iyac038 ]
Haplotype-based inference of the distribution of fitness effects.
Ortega-Del Vecchyo D, Lohmueller KE, Novembre J.
[ Genetics 220(4):iyac002 ]
The background and legacy of Lewontin’s apportionment of human genetic diversity.
Novembre J.
[ Philos Trans R Soc Lond B Biol Sci. 377:20200406 ]
2021
Fast and Flexible Estimation of Effective Migration Surfaces.
Marcus JH, Ha W, Barber RF, Novembre J.
[ eLife 10:e61927 ]
Parental relatedness through time revealed by runs of homozygosity in ancient DNA.
Ringbauer H, Novembre J, Steinrücken M.
[ Nature Communications 12:1-11 ]
2020
Geographic patterns of human allele frequency variation :a variant-centric perspective.
Biddanda A, Rice DP, Novembre J.
[ eLife 9:e60107 ]
Genetic history from the Middle Neolithic to present on the Mediterranean island of Sardinia.
Marcus JH<\em>, Posth C, Ringbauer H<\em>, Lai L, Skeates R, Sidore C, Beckett J, Furtwängler A ,Olivieri A, Chiang CWK<\em>, Al-Asadi H<\em>, Dey KK, Joseph TA, Der Sarkissian C, Radzevičiūtė R, Gradoli MG, Haak W, Reich D, Schlessinger D, Cucca F, Krause J, Novembre J.
[ Nature Communications 11:939 ]
Exploring Population Structure with Admixture Models and Principal Component Analysis.
Liu CC<\em>, Shringarpure S, Lange K, Novembre J.
[ Statistical Population Genomics, Springer Press pp 67-86 ]
Genetic landscapes reveal how human genetic diversity aligns with geography.
Peter BM<\em>, Petkova D, Novembre J.
[ Molecular Biology and Evolution 4:943–951 ]
2019
De novo mutation rate estimation in wolves of known pedigree.
Koch E<\em>, Schweizer RM, Schweizer TM, Stahler DR, Smith DW, Wayne RK, Novembre J.
[ Molecular Biology and Evolution 36(11):2536-2547 ]
Estimating recent migration and population-size surfaces.
Al-Asadi H<\em>, Petkova D, Stephens M, Novembre J.
[ PloS Genetics 15(1):e1007908 ]
The effects of demography and genetics on the neutral distribution of quantitative traits.
Koch EM.<\em>
[ Genetics 211(4):1371-1394 ]
2018
Genomic history of the Sardinian people.
Chiang CWK, Marcus JH, Sidore C, Biddanda A, Al-Asadi H, Zoledziewska M, Pitzalis M, Busonero F, Maschio A, Pistis G, Steri M, Angius A, Lohmueller KE, Abecasis GR, Schlessinger D, Cucca F, Novembre J.
[ Nature Genetics 50:1426–1434 ]
Inference and visualization of DNA damage patterns using a grade of membership model.
Al-Asadi H, Dey KK, Novembre J, Stephens M.
[ Bioinfomatics 35(8):1292-1298 ]
Using pseudoalignment and base quality to accurately quantify microbial community composition.
Reppell R, Novembre J.
[ PloS Computational Biology 14(4):e1006096 ]
Tread Lightly Interpreting Polygenic Tests of Selection.
Novembre J, Barton N.
[ Genetics 208(4):1351-1355 ]
Estimating Time to the Common Ancestor for a Beneficial Allele.
Smith J, Coop G, Stephens M, Novembre J.
[ Molecular Biology and Evolution 35(4):1003-1017 ]
Expected patterns of local ancestry in a hybrid zone.
Smith J, Payseur B, Novembre J.
[ bioRxiv ]
2017
Overexpression of the Cytokine BAFF and Autoimmunity Risk.
Steri M, Orrù V, Idda ML, Pitzalis M, Pala M, Zara I, Sidore C, Faà V, Floris M, Deiana M, Asunis I, Porcu E, Mulas A, Piras MG, Lobina M, Lai S, Marongiu M, Serra V, Marongiu M, Sole G, Busonero F, Maschio A, Cusano R, Cuccuru G, Deidda F, Poddie F, Farina G, Dei M, Virdis F, Olla S, Satta MA, Pani M, Delitala A, Cocco E, Frau J, Coghe G, Lorefice L, Fenu G, Ferrigno P, Ban M, Barizzone N, Leone M, Guerini FR, Piga M, Firinu D, Kockum I, Lima Bomfim I, Olsson T, Alfredsson L, Suarez A, Carreira PE, Castillo-Palma MJ, Marcus JH, Congia M, Angius A, Melis M, Gonzalez A, Alarcón Riquelme ME, da Silva BM, Marchini M, Danieli MG, Del Giacco S, Mathieu A, Pani A, Montgomery SB, Rosati G, Hillert J, Sawcer S, D’Alfonso S, Todd JA, Novembre J, Abecasis GR, Whalen MB, Marrosu MG, Meloni A, Sanna S, Gorospe M, Schlessinger D, Fiorillo E, Zoledziewska M, Cucca F.
[ New England Journal of Medicine 376(17):1615-1626 ]
A longitudinal cline characterizes the genetic structure of human populations in the Tibetan plateau.
Jeong C, Peter BM, Basnyat B, Neupane M, Beall CM, Childs G, Craig SR, Novembre J, Di Rienzo A.
[ PLoS One 12(4):e0175885 ]
A Temporal Perspective on the Interplay of Demography and Selection on Deleterious Variation in Humans.
Koch EM, Novembre J.
[ G3 7(3):1027-1037 ]
Visualizing the Geography of Genetic Variants.
Marcus JH, Novembre J.
[ Bioinformatics 33(4):594-595 ]
2016
Pritchard, Stephens, and Donnelly on Population Structure.
Novembre J.
[ Genetics 204:391-393 ]
Recent advances in the study of fine-scale population structure in humans.
Novembre J, Peter B.
[ Current Opinion in Genetics and Development 41:98-105 ]
Demographically-Based Evaluation of Genomic Regions under Selection in Domestic Dogs.
Freedman AH, Schweizer RM, Ortega-Del Vecchyo D, Han E, Davis BW, Gronau I, Silva PM, Galaverni M, Fan Z, Marx P, Lorente-Galdos B, Ramirez O, Hormozdiari F, Alkan C, Vilà C, Squire K, Geffen E, Kusak J, Boyko AR, Parker HG, Lee C, Tadigotla V, Siepel A, Bustamante CD, Harkins TT, Nelson SF, Marques-Bonet T, Ostrander EA, Wayne RK, Novembre J.
[ PLoS Genetics 12:e1005851 ]
Conflations of short IBD blocks can bias inferred length of IBD.
Chiang CWK, Ralph P, Novembre J.
[ G3 6:1287-96 ]
Technical Report- Assessment of the genetic analysis of Rasmussen et al. (2015).
Novembre J, Witonsky D, Di Rienzo A.
[ Report provided to the U.S. Army Corps of Engineers, St. Louis District ]
Visualizing spatial population structure with estimated effective migration surfaces.
Petkova D, Novembre J, Stephens M.
[ Nature Genetics 48:94-100 ]
2015
Height-reducing variants and selection for short stature on the island of Sardinia.
Zoledziewska M, Sidore C, Chiang CWK, Sanna S, Mulas A, Steri M, Busonero F, Marcus JH, Marongiu M, Maschio A, Ortega Del Vecchyo D, Floris M, Meloni A, Delitala A, Concas MP, Murgia F, Biino G, Vaccargiu S, Nagaraja R, Lohmueller KE, UK10K consortium, Timpson NJ, Soranzo N, Tachmazidou I Dedoussis G, Zeggini E, The Understanding Society Scientific Group, Uzzau S, Jones C, Lyons R, Angius A, Abecasis GR, Novembre J, Schlessinger D, Cucca F.
[ Nature Genetics 47:1352-6 ]
Human Evolution - ancient DNA steps into the language debate.
Novembre J.
[ Nature News and Views 11:164-165 ]
Power analysis of artificial selection experiments using efficient whole genome simulation of quantitative traits.
Kessner D, Novembre J.
[ Genetics 199:991-1005 ]
Fast and accurate site frequency spectrum estimation from low coverage sequence data.
Han E, Sinsheimer JS, Novembre J.
[ Bioinformatics 31:720-7 ]
2014
Spatial localization of recent ancestors for admixed individuals.
Yang WY, Platt A, Chiang CW, Eskin E, Novembre J, Pasaniuc B.
[ G3 4:2505-18 ]
Demographic events and evolutionary forces shaping European genetic diversity.
Veeramah KR, Novembre J.
[ Cold Spring Harb Perspect Biol 6(9):a008516 ]
Variations on a Common STRUCTURE - New Algorithms for a Valuable Model.
Novembre, J.
[ Genetics 197:809-811 ]
Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European.
Olalde I, Allentoft ME, Sánchez-Quinto F, Santpere G, Chiang CW, Degiorgio M, Prado-Martinez J, Rodríguez JA, Rasmussen S, Quilez J, Ramírez O, Marigorta UM, Fernández-Callejo M, Prada ME, Encinas JM, Nielsen R, Netea MG, Novembre J, Sturm RA, Sabeti P, Marquès-Bonet T, Navarro A, Willerslev E, Lalueza-Fox C.
[ Nature 507(7491):225-8 ]
Genome sequencing highlights the dynamic early history of dogs.
Freedman AH, Gronau I, Schweizer RM, Ortega-Del Vecchyo D, Han E, Silva PM, Galaverni M, Fan Z, Marx P, Lorente-Galdos B, Beale H, Ramirez O, Hormozdiari F, Alkan C, Vilà C, Squire K, Geffen E, Kusak J, Boyko AR, Parker HG, Lee C, Tadigotla V, Siepel A, Bustamante CD, Harkins TT, Nelson SF, Ostrander EA, Marques-Bonet T, Wayne RK, Novembre J.
[ PLoS Genetics 10:e1004016 ]
Analysis of rare variant population structure in Europeans explains differential stratification of gene-based tests.
Zawistowski M, Reppell M, Wegmann D, St Jean PL, Ehm MG, Nelson MR, Novembre J, Zöllner S.
[ Eur J Hum Genet 22:1137–1144 ]
2013
forqs - forward-in-time simulation of recombination, quantitative traits and selection.
Kessner D, Novembre J.
[ Bioinformatics 30(4):576-7 ]
Characterizing bias in population genetic inferences from low coverage sequencing data.
Han E, Sinsheimer JS, Novembre J.
[ Molecular Biology and Evolution ]
Novel statistical methods for integrating genetic and stable isotope data to infer individual-level migratory connectivity.
Rundel CW, Wunder MB, Alvarado AH, Ruegg KC, Harrigan R, Schuh A, Kelly JF, Siegel RB, Desante DF, Smith TB, Novembre J.
[ Molecular Ecology 22(16):4163-76 ]
Maximum Likelihood Estimation of Frequencies of Known Haplotypes from Pooled Sequence Data.
Kessner D, Turner TL, Novembre J.
[ Molecular Biology and Evolution 30:1145-58 ]
2012
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people.
Nelson MR, Wegmann D, Ehm MG, Kessner D, St Jean P, Verzilli C, Shen J, Tang Z, Bacanu SA, Fraser D, Warren L, Aponte J, Zawistowski M, Liu X, Zhang H, Zhang Y, Li J, Li Y, Li L, Woollard P, Topp S, Hall MD, Nangle K, Wang J, Abecasis G, Cardon LR, Zöllner S, Whittaker JC, Chissoe SL, Novembre J, Mooser V.
[ Science 337:100-4 ]
2011
Genetic variation in the Sorbs of eastern Germany in the context of broader European genetic diversity.
Veeramah KR, Tönjes A, Kovacs P, Gross A, Wegmann D, Geary P, Gasperikova D, Klimes I, Scholz M, Novembre J, Stumvoll M.
[ European Journal of Human Genetics 19(9):995-1001 ]
Perspectives on human population structure at the cusp of the sequencing era.
Novembre J, Ramachandran S.
[ Annual Review of Genomics and Human Genetics 12:245-74 ]
Recombination rates in admixed individuals identified by ancestry-based inference.
Wegmann D, Kessner DE, Veeramah KR, Mathias RA, Nicolae DL, Yanek LR, Sun YV, Torgerson DG, Rafaels N, Mosley T, Becker LC, Ruczinski I, Beaty TH, Kardia SL, Meyers DA, Barnes KC, Becker DM, Freimer NB, Novembre J.
[ Nature Genetics 43:847-53 ]
A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids.
vonHoldt BM, Pollinger JP, Earl DA, Knowles JC, Boyko AR, Parker H, Geffen E, Pilot M, Jedrzejewski W, Jedrzejewska B, Sidorovich V, Greco C, Randi E, Musiani M, Kays R, Bustamante CD, Ostrander EA, Novembre J, Wayne RK.
[ Genome Research 21:1294-305 ]
2010
Principal component analysis under population genetic models of range expansion and admixture.
François O, Currat M, Ray N, Han E, Excoffier L, Novembre J.
[ Molecular Biology and Evolution 27:1257-68 ]
Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication.
vonHoldt BM, Pollinger JP, Lohmueller KE, Han E, Parker HG, Quignon P, Degenhardt JD, Boyko AR, Earl DA, Auton A, Reynolds A, Bryc K, Brisbin A, Knowles JC, Mosher DS, Spady TC, Elkahloun A, Geffen E, Pilot M, Jedrzejewski W, Greco C, Randi E, Bannasch D, Wilton A, Shearman J, Musiani M, Cargill M, Jones PG, Qian Z, Huang W, Ding ZL, Zhang YP, Bustamante CD, Ostrander EA, Novembre J, Wayne RK.
[ Nature 464:898-902 ]
2009
Likelihood-based inference in isolation-by-distance models using the spatial distribution of low-frequency alleles.
Novembre J, Slatkin M.
[ Evolution 63:2914-25 ]
Spatial patterns of variation due to natural selection in humans.
Novembre J, Di Rienzo A.
[ Nature Reviews Genetics 10:745-55 ]
Fast model-based estimation of ancestry in unrelated individuals.
Alexander DH, Novembre J, Lange K.
[ Genome Research 19:1655-64 ]
The role of geography in human adaptation.
Coop G, Pickrell JK, Novembre J, Kudaravalli S, Li J, Absher D, Myers RM, Cavalli-Sforza LL, Feldman MW, Pritchard JK.
[ PLoS Genetics 5:e1000500 ]
Signals of recent positive selection in a worldwide sample of human populations.
Pickrell JK, Coop G, Novembre J, Kudaravalli S, Li JZ, Absher D, Srinivasan BS, Barsh GS, Myers RM, Feldman MW, Pritchard JK.
[ Genome Research 19:826-37 ]
Global distribution of genomic diversity underscores rich complex history of continental human populations.
Auton A, Bryc K, Boyko AR, Lohmueller KE, Novembre J, Reynolds A, Indap A, Wright MH, Degenhardt JD, Gutenkunst RN, King KS, Nelson MR, Bustamante CD.
[ Genome Research 19:795-803 ]
2008
Genes mirror geography within Europe.
Novembre J, Johnson T, Bryc K, Kutalik Z, Boyko AR, Auton A, Indap A, King KS, Bergmann S, Nelson MR, Stephens M, Bustamante CD.
[ Nature 456:98-101 ]
The Population Reference Sample, POPRES - a resource for population, disease, and pharmacological genetics research.
Nelson MR, Bryc K, King KS, Indap A, Boyko AR, Novembre J, Briley LP, Maruyama Y, Waterworth DM, Waeber G, Vollenweider P, Oksenberg JR, Hauser SL, Stirnadel HA, Kooner JS, Chambers JC, Jones B, Mooser V, Bustamante CD, Roses AD, Burns DK, Ehm MG, Lai EH.
[ American Journal of Human Genetics 83:347-58 ]
Interpreting principal component analyses of spatial population genetic variation.
Novembre J, Stephens M.
[ Nature Genetics 40:646-9 ]
2007 - 2000
Ascertainment bias in spatially structured populations - A case study in the eastern fence lizard
Rosenblum EB, Novembre J.
[ The Journal of Heredity 98:331-6 ]
The geographic spread of the CCR5 Delta32 HIV-resistance allele.
Novembre J, Galvani AP, Slatkin M.
[ PLoS Biology 3:e339 ]
Finding haplotype block boundaries by using the minimum-description-length principle.
Anderson EC, Novembre J.
[ American Journal of Human Genetics 73:336-54 ]
Accounting for background nucleotide composition when measuring codon usage bias.
Novembre J.
[ Molecular Biology and Evolution 19:1390-4 ]
SIMCOAL- a general coalescent program for the simulation of molecular data in interconnected populations with arbitrary demography.
Excoffier L, Novembre J, Schneider S.
[ The Journal of heredity 91:506-9 ]